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Infection and Immunity, April 2005, p. 1986-1994, Vol. 73, No. 4
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.4.1986-1994.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Fatal Plasmodium falciparum Malaria Causes Specific Patterns of Splenic Architectural Disorganization

Britta C. Urban,1* Tran T. Hien,2 Nicholas P. Day,1,3 Nguyen H. Phu,2 Rachel Roberts,4 Emsri Pongponratn,3 Margret Jones,4 Nguyen T. H. Mai,2 Delia Bethell,3 Gareth D. H. Turner,4 David Ferguson,4 Nicholas J. White,1,3 and David J. Roberts4,5

Nuffield Department of Clinical Medicine,1 Nuffield Department of Clinical Laboratory Sciences, University of Oxford,4 National Blood Service, John Radcliffe Hospital, Oxford, United Kingdom,5 Centre for Tropical Diseases, Cho Quan Hospital, Ho Chi Minh City, Vietnam,2 Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand3

Received 7 July 2004/ Returned for modification 23 August 2004/ Accepted 14 December 2004

The spleen is critical for host defense against pathogens, including Plasmodium falciparum. It has a dual role, not only removing aged or antigenically altered erythrocytes from the blood but also as the major lymphoid organ for blood-borne or systemic infections. The human malaria parasite P. falciparum replicates within erythrocytes during asexual blood stages and causes repeated infections that can be associated with severe disease. In spite of the crucial role of the spleen in the innate and acquired immune response to malaria, there is little information on the pathology of the spleen in human malaria. We performed a histological and quantitative immunohistochemical study of spleen sections from Vietnamese adults dying from severe falciparum malaria and compared the findings with the findings for spleen sections from control patients and patients dying from systemic bacterial sepsis. Here we report that the white pulp in the spleens of patients dying from malaria showed a marked architectural disorganization. We observed a marked dissolution of the marginal zones with relative loss of B cells. Furthermore, we found strong HLA-DR expression on sinusoidal lining cells but downregulation on cordal macrophages. P. falciparum infection results in alterations in splenic leukocytes, many of which are not seen in sepsis.

* Corresponding author. Mailing address: Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, University of Oxford, Old Road, Oxford, OX3 7LJ, United Kingdom. Phone: 44-1865-857436. Fax: 44-1865-857407. E-mail: britta.urban{at}ndm.ox.ac.uk.

Editor: J. F. Urban, Jr.

Infection and Immunity, April 2005, p. 1986-1994, Vol. 73, No. 4
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.4.1986-1994.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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