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Infection and Immunity, April 2005, p. 2547-2549, Vol. 73, No. 4
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.4.2547-2549.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Isocitrate Lyase (AceA) Is Required for Salmonella Persistence but Not for Acute Lethal Infection in Mice

Ferric C. Fang,* Stephen J. Libby, Margaret E. Castor, and Angela M. Fung

Departments of Laboratory Medicine and Microbiology, University of Washington School of Medicine, Seattle, Washington

Received 20 September 2004/ Returned for modification 5 October 2005/ Accepted 22 November 2005

Isocitrate lyase is required for fatty acid utilization via the glyoxylate shunt. Although isocitrate lyase is essential for Salmonella persistence during chronic infection, it is dispensable for acute lethal infection in mice. Substrate availability in the phagosome appears to evolve over time, with increasing fatty acid dependence during chronic infection.

* Corresponding author. Mailing address: Departments of Laboratory Medicine and Microbiology, University of Washington School of Medicine, 1959 NE Pacific St., Box 357242, Seattle, WA 98195-7242. Phone: (206) 221-6770. Fax: (206) 616-1575. E-mail: fcfang{at}u.washington.edu.

Editor: A. D. O'Brien

Infection and Immunity, April 2005, p. 2547-2549, Vol. 73, No. 4
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.4.2547-2549.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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