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Infection and Immunity, April 2005, p. 2554-2555, Vol. 73, No. 4
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.4.2554-2555.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

The Mannose Receptor Mediates the Cellular Immune Response in Human Coccidioidomycosis

Neil M. Ampel,1,2,3* Daniel K. Nelson,3 Lijin Li,2 Sara O. Dionne,2,4 Douglas F. Lake,2,4 Keira A. Simmons,5 and Demosthenes Pappagianis5

Department of Medicine,1 Department of Microbiology and Immunology,2 Arizona Cancer Center, University of Arizona Health Sciences Center,4 Medical and Research Services, Southern Arizona Veterans Affairs Medical Center, Tucson, Arizona,3 Department of Microbiology and Immunology, University of California at Davis, Davis, California5

Received 30 June 2004/ Returned for modification 3 August 2004/ Accepted 2 December 2004

Mannose is the predominant monosaccharide in the coccidioidal antigen preparation T27K. Mannan and anti-CD206 antibody significantly decreased the surface expression of mannose receptor (MR) on adherent peripheral blood mononuclear cells and reduced the interleukin-2 (IL-2) release induced by T27K. These data suggest that MR mediates IL-2 release by T27K.

* Corresponding author. Mailing address: Medical Service (1-111), SAVAHCS, 3601 S. Sixth Ave., Tucson, AZ 85723. Phone: (520) 792-1450. Fax: (520) 629-1861. E-mail: nampel{at}email.arizona.edu.

Editor: T. R. Kozel

Infection and Immunity, April 2005, p. 2554-2555, Vol. 73, No. 4
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.4.2554-2555.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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