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Infection and Immunity, April 2005, p. 2559-2563, Vol. 73, No. 4
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.4.2559-2563.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Nonopsonic Phagocytosis of Erythrocytes Infected with Ring-Stage Plasmodium falciparum

Kodjo Ayi,1 Samir N. Patel,1 Lena Serghides,1 Todd G. Smith,1 and Kevin C. Kain1,2,3*

Department of Medicine,1 McLaughlin-Rotman Center for Global Health, McLaughlin Center for Molecular Medicine, University of Toronto,2 Tropical Disease Unit, Toronto General Hospital, Toronto, Ontario, Canada3

Received 13 September 2004/ Returned for modification 13 October 2004/ Accepted 2 December 2004

Ring-stage parasitized erythrocytes (RPEs) were demonstrated to interact with effector cells of the innate immune system. With receptor blockade studies and CD36-null macrophages, human and murine macrophages were shown to phagocytose RPEs through the pattern recognition receptor CD36. These in vitro data implicate scavenger receptors in the clearance of RPEs.

* Corresponding author. Mailing address: Toronto General Hospital, 9ES-412, 200 Elizabeth St., Toronto, Ontario, Canada M5G 2C4. Phone: (416) 340-3535. Fax: (416) 595-5826. E-mail: kevin.kain{at}uhn.on.ca.

Editor: W. A. Petri, Jr.

Infection and Immunity, April 2005, p. 2559-2563, Vol. 73, No. 4
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.4.2559-2563.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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