This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Steigerwald, M.
Right arrow Articles by Moll, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Steigerwald, M.
Right arrow Articles by Moll, H.

 Previous Article  |  Next Article 

Infection and Immunity, April 2005, p. 2564-2567, Vol. 73, No. 4
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.4.2564-2567.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Leishmania major Modulates Chemokine and Chemokine Receptor Expression by Dendritic Cells and Affects Their Migratory Capacity

Mario Steigerwald and Heidrun Moll*

Institute for Molecular Biology of Infectious Diseases, University of Würzburg, Würzburg, Germany

Received 6 May 2004/ Returned for modification 23 June 2004/ Accepted 10 December 2004

Dendritic cells (DC) both produce and respond to chemokines. We examined the profiles of chemokines and chemokine receptors expressed by DC and their chemotactic response after interaction with Leishmania major. Expression of the chemokine receptors CCR2 and CCR5 by DC and their responsiveness to the respective ligands, CCL2 and CCL3, were downregulated, while the level of CCR7 and the DC response to its ligand CCL21 were enhanced. These parasite-induced alterations were observed with DC from L. major-resistant and -susceptible mice. In contrast, expression of the chemokine CXCL10 was elicited only in DC from L. major-resistant mice.

* Corresponding author. Mailing address: Institut für Molekulare Infektionsbiologie, Universität Würzburg, Röntgenring 11, 97070 Würzburg, Germany. Phone: 49 931 312627. Fax: 49 931 312578. E-mail: heidrun.moll{at}mail.uni-wuerzburg.de.

Editor: S. H. E. Kaufmann

Infection and Immunity, April 2005, p. 2564-2567, Vol. 73, No. 4
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.4.2564-2567.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Soong, L. (2008). Modulation of Dendritic Cell Function by Leishmania Parasites. J. Immunol. 180: 4355-4360 [Abstract] [Full Text]  
  • Vasquez, R. E., Xin, L., Soong, L. (2008). Effects of CXCL10 on Dendritic Cell and CD4+ T-Cell Functions during Leishmania amazonensis Infection. Infect. Immun. 76: 161-169 [Abstract] [Full Text]  
  • Unsoeld, H., Mueller, K., Schleicher, U., Bogdan, C., Zwirner, J., Voehringer, D., Pircher, H. (2007). Abrogation of CCL21 chemokine function by transgenic over-expression impairs T cell immunity to local infections. Int Immunol 19: 1281-1289 [Abstract] [Full Text]  
  • Vasquez, R. E., Soong, L. (2006). CXCL10/Gamma Interferon-Inducible Protein 10-Mediated Protection against Leishmania amazonensis Infection in Mice. Infect. Immun. 74: 6769-6777 [Abstract] [Full Text]  
  • Pinheiro, N. F. Jr., Hermida, M. D. R., Macedo, M. P., Mengel, J., Bafica, A., dos-Santos, W. L. C. (2006). Leishmania Infection Impairs {beta}1-Integrin Function and Chemokine Receptor Expression in Mononuclear Phagocytes. Infect. Immun. 74: 3912-3921 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»