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Infection and Immunity, May 2005, p. 3128-3136, Vol. 73, No. 5
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.5.3128-3136.2005

The Bartonella vinsonii subsp. arupensis Immunodominant Surface Antigen BrpA Gene, Encoding a 382-Kilodalton Protein Composed of Repetitive Sequences, Is a Member of a Multigene Family Conserved among Bartonella Species

Robert D. Gilmore Jr.,^1* Travis M. Bellville,^1, Steven L. Sviat,¹ and Michael Frace²

Bacterial Zoonoses Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado,¹ Genome Sequencing Laboratory Biotechnology Core Facility, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia²

Received 27 December 2004/ Accepted 11 January 2005

Bartonella proteins that elicit an antibody response during an infection are poorly defined; therefore, to characterize antigens recognized by the host, a Bartonella genomic expression library was screened with serum from an infected mouse. This process led to the discovery of a Bartonella vinsonii subsp. arupensis gene encoding a 382-kDa protein, part of a gene family encoding large proteins, each containing multiple regions of repetitive segments. The genes were termed brpA to -C (bartonella repeat protein) and bore significant similarity to genes encoding the BadA adhesin protein and members of the variably expressed outer membrane protein family of proteins from Bartonella henselae and Bartonella quintana, respectively.

Editor: V. J. DiRita

Present address: Microbiology and Molecular Genetics Dept., University of Vermont, Burlington, VT 05405.

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