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Infection and Immunity, May 2005, p. 3137-3146, Vol. 73, No. 5
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.5.3137-3146.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Surface Analyses and Immune Reactivities of Major Cell Wall-Associated Proteins of Group A Streptococcus

Jason N. Cole,1 Ruben D. Ramirez,1 Bart J. Currie,2 Stuart J. Cordwell,3 Steven P. Djordjevic,4 and Mark J. Walker1*

School of Biological Sciences, University of Wollongong, Wollongong, NSW,1 Menzies School of Health Research, Charles Darwin University, Darwin, NT,2 Australian Proteome Analysis Facility, Macquarie University, Sydney, NSW,3 NSW Agriculture, Elizabeth Macarthur Agricultural Institute, Camden, NSW, Australia4

Received 9 December 2004/ Accepted 27 December 2004

A proteomic analysis was undertaken to identify cell wall-associated proteins of Streptococcus pyogenes. Seventy-four distinct cell wall-associated proteins were identified, 66 of which were novel. Thirty-three proteins were immunoreactive with pooled S. pyogenes-reactive human antisera. Biotinylation of the GAS cell surface identified 23 cell wall-associated proteins that are surface exposed.

* Corresponding author. Mailing address: School of Biological Sciences, University of Wollongong, Wollongong, NSW 2522, Australia. Phone: 0061-242-213439. Fax: 0061-242-214135. E-mail: mwalker{at}uow.edu.au.

Editor: V. J. DiRita

Infection and Immunity, May 2005, p. 3137-3146, Vol. 73, No. 5
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.5.3137-3146.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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