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Infection and Immunity, May 2005, p. 3147-3151, Vol. 73, No. 5
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.5.3147-3151.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

A Hypothetical Protein of Streptococcus mutans Is Critical for Biofilm Formation

Thomas A. Brown Jr., Sang-Joon Ahn, Roslyn N. Frank, Yi-Ywan M. Chen, José A. Lemos, and Robert A. Burne*

Department of Oral Biology, University of Florida College of Dentistry, 1600 SW Archer Rd., Gainesville, Florida 32610-0424

Received 30 July 2004/ Returned for modification 11 October 2004/ Accepted 4 January 2005

Inactivation of the Smu0630 gene of Streptococcus mutans resulted in dramatic decreases in biofilm formation, regardless of the carbohydrate source. The Smu0630 protein contained numerous interesting features, including a possible signal sequence and two conserved regions of repeated sequences. Smu0630 may represent a potential target for novel therapeutics.

* Corresponding author. Mailing address: Department of Oral Biology, University of Florida College of Dentistry, 1600 SW Archer Rd., Gainesville, FL 32610-0424. Phone: (352) 392-4370. Fax: (352) 392-7357. E-mail: rburne{at}dental.ufl.edu.

Editor: V. J. DiRita

Infection and Immunity, May 2005, p. 3147-3151, Vol. 73, No. 5
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.5.3147-3151.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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