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Infection and Immunity, May 2005, p. 3147-3151, Vol. 73, No. 5
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.5.3147-3151.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

A Hypothetical Protein of Streptococcus mutans Is Critical for Biofilm Formation

Department of Oral Biology, University of Florida College of Dentistry, 1600 SW Archer Rd., Gainesville, Florida 32610-0424

Received 30 July 2004/ Returned for modification 11 October 2004/ Accepted 4 January 2005

Inactivation of the Smu0630 gene of Streptococcus mutans resulted in dramatic decreases in biofilm formation, regardless of the carbohydrate source. The Smu0630 protein contained numerous interesting features, including a possible signal sequence and two conserved regions of repeated sequences. Smu0630 may represent a potential target for novel therapeutics.

Editor: V. J. DiRita

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