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Infection and Immunity, May 2005, p. 3164-3165, Vol. 73, No. 5
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.5.3164-3165.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Tumor Necrosis Factor Alpha Plays a Role in the Acceleration of Atherosclerosis by Chlamydia pneumoniae in Mice

Lee Ann Campbell, Tadayoshi Nosaka, Michael E. Rosenfeld, Kambiz Yaraei, and Cho-chou Kuo*

Department of Pathobiology, University of Washington, Seattle, Washington

Received 19 November 2004/ Returned for modification 22 December 2004/ Accepted 4 January 2005

The role of tumor necrosis factor alpha (TNF-{alpha}) in Chlamydia pneumoniae atherogenesis was evaluated in TNF-{alpha} p55 receptor-deficient C57BL/6J mice fed a high-fat/high-cholesterol diet. No acceleration of atherosclerotic lesion development was observed in infected mice compared to uninfected mice, indicating that TNF-{alpha} plays a role in the acceleration of atherosclerosis by C. pneumoniae.

* Corresponding author. Mailing address: Department of Pathobiology, Box 357238, University of Washington, Seattle, WA 98195. Phone: (206) 543-8689. Fax: (206) 543-3873. E-mail: cckuo{at}u.washington.edu.

Editor: J. N. Weiser

Infection and Immunity, May 2005, p. 3164-3165, Vol. 73, No. 5
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.5.3164-3165.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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