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Infection and Immunity, May 2005, p. 3172-3177, Vol. 73, No. 5
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.5.3172-3177.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Interleukin-15 Enhances Innate and Adaptive Immune Responses to Blood-Stage Malaria Infection in Mice

Rebecca Ing,1 Philippe Gros,1,2 and Mary M. Stevenson1*

Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre,1 Department of Biochemistry, McGill University, Montreal, Quebec, Canada2

Received 1 October 2004/ Returned for modification 4 November 2004/ Accepted 15 December 2004

Compared to C57BL/6 wild-type mice, interleukin-15–/– (IL-15–/–) mice showed delayed clearance of Plasmodium chabaudi AS infection, lower type 1 cytokine production, impaired dendritic cell and NK cell functions, and lower titers of malaria-specific antibodies. Thus, IL-15 supports early control and timely resolution of blood-stage malaria through promotion of Th1-dependent innate and adaptive immune responses.

* Corresponding author. Mailing address: Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, 1650 Cedar Ave., Montreal, Quebec H3G 1A4, Canada. Phone: (514) 934-1934, ext. 44507. Fax: (514) 934-8332. E-mail: mary.m.stevenson{at}mcgill.ca.

Editor: W. A. Petri, Jr.

Infection and Immunity, May 2005, p. 3172-3177, Vol. 73, No. 5
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.5.3172-3177.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Ing, R., Stevenson, M. M. (2009). Dendritic Cell and NK Cell Reciprocal Cross Talk Promotes Gamma Interferon-Dependent Immunity to Blood-Stage Plasmodium chabaudi AS Infection in Mice. Infect. Immun. 77: 770-782 [Abstract] [Full Text]  
  • Murray, H. W., Tsai, C. W., Liu, J., Ma, X. (2006). Responses to Leishmania donovani in Mice Deficient in Interleukin-12 (IL-12), IL-12/IL-23, or IL-18. Infect. Immun. 74: 4370-4374 [Abstract] [Full Text]  
  • Cernetich, A., Garver, L. S., Jedlicka, A. E., Klein, P. W., Kumar, N., Scott, A. L., Klein, S. L. (2006). Involvement of gonadal steroids and gamma interferon in sex differences in response to blood-stage malaria infection.. Infect. Immun. 74: 3190-3203 [Abstract] [Full Text]  
  • Ing, R., Segura, M., Thawani, N., Tam, M., Stevenson, M. M. (2006). Interaction of Mouse Dendritic Cells and Malaria-Infected Erythrocytes: Uptake, Maturation, and Antigen Presentation. J. Immunol. 176: 441-450 [Abstract] [Full Text]  


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