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Infection and Immunity, May 2005, p. 3172-3177, Vol. 73, No. 5
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.5.3172-3177.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Interleukin-15 Enhances Innate and Adaptive Immune Responses to Blood-Stage Malaria Infection in Mice

Rebecca Ing,1 Philippe Gros,1,2 and Mary M. Stevenson1*

Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre,1 Department of Biochemistry, McGill University, Montreal, Quebec, Canada2

Received 1 October 2004/ Returned for modification 4 November 2004/ Accepted 15 December 2004

Compared to C57BL/6 wild-type mice, interleukin-15–/– (IL-15–/–) mice showed delayed clearance of Plasmodium chabaudi AS infection, lower type 1 cytokine production, impaired dendritic cell and NK cell functions, and lower titers of malaria-specific antibodies. Thus, IL-15 supports early control and timely resolution of blood-stage malaria through promotion of Th1-dependent innate and adaptive immune responses.

* Corresponding author. Mailing address: Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, 1650 Cedar Ave., Montreal, Quebec H3G 1A4, Canada. Phone: (514) 934-1934, ext. 44507. Fax: (514) 934-8332. E-mail: mary.m.stevenson{at}mcgill.ca.

Editor: W. A. Petri, Jr.

Infection and Immunity, May 2005, p. 3172-3177, Vol. 73, No. 5
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.5.3172-3177.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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