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Infection and Immunity, May 2005, p. 3178-3183, Vol. 73, No. 5
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.5.3178-3183.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Regulation of the Mitogen-Activated Protein Kinases by Brucella spp. Expressing a Smooth and Rough Phenotype: Relationship to Pathogen Invasiveness

María P. Jiménez de Bagüés,1* Antoine Gross,2 Annie Terraza,2 and Jacques Dornand2

Centro de Investigación y Tecnología Agroalimentaria de Aragón (CITA), Gobierno de Aragón, Ap. 727, 50080 Zaragoza, Spain,1 INSERM U431, Université de Montpellier II, Place Eugène Bataillon, CC 100, 34095-Montpellier, France2

Received 21 October 2004/ Returned for modification 26 November 2004/ Accepted 16 December 2004

By comparing smooth wild-type Brucella spp. to their rough mutants, we show that the LPS O chain restricted the activation of the ERK1/2 and p38 mitogen-activated protein kinase (MAPK) pathways, thus preventing the synthesis of immune mediators that regulate host defense. We conclude that the MAPKs are a target for immune intervention by virulent smooth Brucella.

* Corresponding author. Mailing address: Centro de Investigación y Tecnología Agroalimentaria de Aragón (CITA), Gobierno de Aragón, Ap. 727, 50080 Zaragoza, Spain. Phone: 34-976-716-457. Fax: 34-976-716-335. E-mail: mpjimenezdebagues{at}aragon.es.

Editor: D. L. Burns

Infection and Immunity, May 2005, p. 3178-3183, Vol. 73, No. 5
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.5.3178-3183.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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