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Infection and Immunity, May 2005, p. 3184-3187, Vol. 73, No. 5
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.5.3184-3187.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

The Concentration of Apolipoprotein A-I Decreases during Experimentally Induced Acute-Phase Processes in Pigs

R. Carpintero,1 M. Piñeiro,1 M. Andrés,1 M. Iturralde,1 M. A. Alava,1 P. M. H. Heegaard,2 J. L. Jobert,3 F. Madec,3 and F. Lampreave1*

Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Spain,1 Danish Institute for Food and Veterinary Research, Copenhagen V, Denmark,2 French Agency for Food Safety, BP 53, Zoôpoles les Croix, 22440 Ploufragan, France3

Received 27 September 2004/ Returned for modification 15 November 2004/ Accepted 17 December 2004

In this work, apolipoprotein A-I (ApoA-I) was purified from pig sera. The responses of this protein after sterile inflammation and in animals infected with Actinobacillus pleuropneumoniae or Streptococcus suis were investigated. Decreases in the concentrations of ApoA-I, two to five times lower than the initial values, were observed at 2 to 4 days. It is concluded that ApoA-I is a negative acute-phase protein in pigs.

* Corresponding author. Mailing address: Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, 50009 Zaragoza, Spain. Phone: (34) 976 761 284. Fax: (34) 976 762 123. E-mail: lampreav{at}unizar.es.

Editor: F. C. Fang

Infection and Immunity, May 2005, p. 3184-3187, Vol. 73, No. 5
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.5.3184-3187.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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