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Infection and Immunity, May 2005, p. 3192-3195, Vol. 73, No. 5
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.5.3192-3195.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

The Purinergic P2X7 Receptor Is Not Required for Control of Pulmonary Mycobacterium tuberculosis Infection

Amy J. Myers,1 Brandon Eilertson,2 Scott A. Fulton,2 JoAnne L. Flynn,1 and David H. Canaday2*

Department of Medicine, Division of Infectious Disease, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106,1 Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 152612

Received 18 October 2004/ Returned for modification 30 November 2004/ Accepted 14 January 2005

The importance in vivo of P2X7 receptors in control of virulent Mycobacterium tuberculosis was examined in a low-dose aerosol infection mouse model. P2X7–/– mice controlled infection in lungs as well as wild-type mice, suggesting that the P2X7 receptor is not required for control of pulmonary M. tuberculosis infection.

* Corresponding author. Mailing address: Department of Medicine, Division of Infectous Disease, BRB 1029, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4984. Phone: (216) 368-8901. Fax: (216) 368-2034. E-mail: david.canaday{at}case.edu.

Editor: J. D. Clements

Infection and Immunity, May 2005, p. 3192-3195, Vol. 73, No. 5
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.5.3192-3195.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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