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Infection and Immunity, June 2005, p. 3659-3667, Vol. 73, No. 6
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.6.3659-3667.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Characterization of CD8+ T Cells and Microenvironment in Oral Lesions of Human Immunodeficiency Virus-Infected Persons with Oropharyngeal Candidiasis

Kelly M. McNulty,3,5 Jananya Plianrungsi,1 Janet E. Leigh,2,5 Donald Mercante,4,5 and Paul L. Fidel Jr.3,5*

Department of Oral Medicine,1 Department of General Dentistry,2 Department of Microbiology, Immunology, and Parasitology,3 Dentistry and Biometerials,4 Center of Excellence in Oral and Craniofacial Biology, Louisiana State University School of Dentistry, 1100 Florida Avenue, New Orleans, Louisiana 701195

Received 13 December 2004/ Returned for modification 14 January 2005/ Accepted 10 February 2005

Oropharyngeal candidiasis (OPC), the most common oral infection in human immunodeficiency virus-positive persons, correlates with reduced blood CD4+ T cells. In those with OPC, CD8+ T cells accumulate at the lamina propria-epithelium interface at a distance from the organism at the outer epithelium. The present study aimed to characterize the tissue-associated CD8+ T cells and tissue microenvironment in both OPC+ and OPC– persons. The results show that the majority of CD8+ T cells possess the {alpha}ß T-cell receptor, the thymus-derived {alpha}ß CD8 antigen heterodimer, and similar levels of the {alpha}4ß7, {alpha}4ß1, and {alpha}eß7 homing receptors. Studies to evaluate the tissue microenvironment showed that in OPC+ persons, the adhesion molecule for T cells to enter mucosa, mucosal addressin cell adhesion molecule, is significantly increased, whereas E-cadherin, which allows T cells to migrate through mucosa, is significantly decreased compared to OPC– persons. These results continue to support a role for CD8+ T cells against OPC under conditions of reduced numbers of CD4+T cells, with susceptibility to infection potentially associated with a dysfunction in mucosal CD8+ T-cell migration by reduced tissue-associated E-cadherin.

* Corresponding author. Mailing address: Center of Excellence in Oral and Craniofacial Biology, Louisiana State University School of Dentistry, 1100 Florida Avenue, New Orleans, Louisiana 70119. Phone and Fax: (504) 568-4066. E-mail: pfidel{at}lsuhsc.edu.

Editor: T. R. Kozel

Infection and Immunity, June 2005, p. 3659-3667, Vol. 73, No. 6
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.6.3659-3667.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Villar, C. C., Kashleva, H., Nobile, C. J., Mitchell, A. P., Dongari-Bagtzoglou, A. (2007). Mucosal Tissue Invasion by Candida albicans Is Associated with E-Cadherin Degradation, Mediated by Transcription Factor Rim101p and Protease Sap5p. Infect. Immun. 75: 2126-2135 [Abstract] [Full Text]  
  • Leigh, J. E., McNulty, K. M., Fidel, P. L. Jr. (2006). Characterization of the Immune Status of CD8+ T Cells in Oral Lesions of Human Immunodeficiency Virus-Infected Persons with Oropharyngeal Candidiasis. CVI 13: 678-683 [Abstract] [Full Text]  
  • Fidel, P.L. Jr. (2006). Candida-Host Interactions in HIV Disease: Relationships in Oropharyngeal Candidiasis. ADR 19: 80-84 [Abstract] [Full Text]  
  • Dongari-Bagtzoglou, A., Fidel, P.L. Jr. (2005). The Host Cytokine Responses and Protective Immunity in Oropharyngeal Candidiasis. JDR 84: 966-977 [Abstract] [Full Text]  


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