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Infection and Immunity, June 2005, p. 3734-3739, Vol. 73, No. 6
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.6.3734-3739.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Protein Microarray for Profiling Antibody Responses to Yersinia pestis Live Vaccine

Bei Li,1,{dagger} Lingxiao Jiang,2,{dagger} Qifeng Song,3,4,{dagger} Junxin Yang,1 Zeliang Chen,1 Zhaobiao Guo,1 Dongsheng Zhou,1 Zongmin Du,1 Yajun Song,1 Jin Wang,1 Hongxia Wang,1 Shouyi Yu,2 Jian Wang,3 and Ruifu Yang1*

Laboratory of Analytical Microbiology, National Center for Biomedical Analysis, Army Center for Microbial Detection and Research, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China,1 The South Medical University, Guangzhou, China,2 Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 100101, China,3 Graduate school of Chinese academy of Sciences, Beijing 100039, China4

Received 20 October 2004/ Returned for modification 24 November 2004/ Accepted 6 January 2005

A protein microarray representing 149 Yersinia pestis proteins was developed to profile antibody responses in EV76-immunized rabbits. Antibodies to 50 proteins were detected. There are 11 proteins besides F1 and V antigens to which the predominant antibody response occurred, and these proteins show promise for further evaluation as candidates for subunit vaccines and/or diagnostic antigens.

* Corresponding author. Mailing address: Laboratory of Analytical Microbiology, National Center for Biomedical Analysis, Army Center for Microbial Detection and Research, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China. Phone: 86-10-66948594. Fax: 86-10-83820748. E-mail: yangrf{at}nic.bmi.ac.cn.

Editor: J. B. Bliska

{dagger} B.L, L.J., and Q.S. contributed equally to this work.

Infection and Immunity, June 2005, p. 3734-3739, Vol. 73, No. 6
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.6.3734-3739.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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