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Infection and Immunity, June 2005, p. 3740-3744, Vol. 73, No. 6
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.6.3740-3744.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Deletion of the Ferric Uptake Regulator Fur Impairs the In Vitro Growth and Virulence of Actinobacillus pleuropneumoniae

Ilse Jacobsen,1 Jörg Gerstenberger,1 Achim D. Gruber,2 Janine T. Bossé,3 Paul R. Langford,3 Isabel Hennig-Pauka,1,4 Jochen Meens,1 and Gerald-F. Gerlach1*

Department of Infectious Diseases, Institute for Microbiology,1 Department of Pathology,2 Clinic for Pigs and Small Ruminants, University of Veterinary Medicine Hannover Foundation, Hannover, Germany,4 Department of Paediatrics, Imperial College London, St. Mary's Campus, London W2 1PG, United Kingdom3

Received 14 December 2004/ Returned for modification 24 January 2005/ Accepted 14 February 2005

In order to investigate the role of the ferric uptake regulator Fur in the porcine lung pathogen Actinobacillus pleuropneumoniae, we constructed an isogenic in-frame deletion mutant, A. pleuropneumoniae {Delta}fur. This mutant showed constitutive expression of transferrin-binding proteins, growth deficiencies in vitro, and reduced virulence in an aerosol infection model.

* Corresponding author. Mailing address: Institut für Mikrobiologie, Zentrum für Infektionsmedizin, Stiftung Tierärztliche Hochschule Hannover, Bischofsholer Damm 15, 30173 Hannover, Germany. Phone: 49-511-856 7598. Fax: 49-511-856 7697. E-mail: gfgerlach{at}gmx.de.

Editor: F. C. Fang

Infection and Immunity, June 2005, p. 3740-3744, Vol. 73, No. 6
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.6.3740-3744.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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