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Infection and Immunity, June 2005, p. 3745-3748, Vol. 73, No. 6
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.6.3745-3748.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Endogenous Interleukin-6 Plays a Crucial Protective Role in Streptococcal Toxic Shock Syndrome via Suppression of Tumor Necrosis Factor Alpha Production

Division of Molecular Immunology, Institute for Genetic Medicine,¹ Department of Microbiology, School of Medicine, Hokkaido University, Sapporo, Japan²

Received 16 November 2004/ Accepted 1 February 2005

During a Streptococcus pyogenes infection in interleukin-6 (IL-6)-deficient mice, there is elevation of serum tumor necrosis factor alpha (TNF-) levels, muscular necrosis, and death compared with infection of C57BL/6 mice. Anti-TNF- monoclonal antibody treatment decreased mortality and muscular necrosis in the infected IL-6-deficient mice. These results suggest that IL-6 plays a crucial protective role via suppression of TNF- production in S. pyogenes infection.

Editor: V. J. DiRita

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