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Infection and Immunity, June 2005, p. 3749-3753, Vol. 73, No. 6
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.6.3749-3753.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Genetic Basis for Conversion of Rough-to-Smooth Colony Morphology in Actinobacillus actinomycetemcomitans

Ying Wang, Amy Liu, and Casey Chen*

University of Southern California School of Dentistry, Los Angeles, California

Received 18 January 2005/ Accepted 8 February 2005

The basis of the rough-to-smooth conversion of Actinobacillus actinomycetemcomitans was examined. Smooth variants often contained mutations at the flp promoter region. Replacing the mutated flp promoter with the wild-type promoter restored the rough phenotype. The expression level of the flp promoter was ~100-fold lower in smooth than in rough strains. Mutations of the flp promoter are a cause of the rough-to-smooth conversion.

* Corresponding author. Mailing address: Division of Primary Oral Health Care, University of Southern California School of Dentistry, 925 W. 34th Street, Los Angeles, CA 90089-0641. Phone: (213) 740-1075. Fax: (213) 740-6778. E-mail: ccchen{at}usc.edu.

Editor: V. J. DiRita

Infection and Immunity, June 2005, p. 3749-3753, Vol. 73, No. 6
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.6.3749-3753.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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