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Infection and Immunity, June 2005, p. 3754-3757, Vol. 73, No. 6
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.6.3754-3757.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Responses of Mycobacterium tuberculosis to Growth in the Mouse Lung

Eugenie Dubnau,1 John Chan,2 V. P. Mohan,2 and Issar Smith1*

TB Center, The Public Health Research Institute, 225 Warren Street Newark, New Jersey 07103,1 Montefiore Medical Center, Bronx, New York 104672

Received 22 September 2004/ Returned for modification 19 November 2004/ Accepted 28 January 2005

Using a promoter trap, we have identified 56 Mycobacterium tuberculosis genes preferentially expressed in the mouse lung. Quantitative real-time PCR showed that RNA levels of several genes were higher from bacteria growing in mouse lungs than from broth cultures. These results support the current hypothesis that Mycobacterium tuberculosis utilizes fatty acids as a carbon source in the mouse lung.

* Corresponding author. Mailing address: The Public Health Research Institute, 225 Warren Street, Newark, NJ 07103. Phone: (973) 854-3262. Fax: (973) 854-3261. E-mail: smitty{at}phri.org.

Editor: J. L. Flynn

Infection and Immunity, June 2005, p. 3754-3757, Vol. 73, No. 6
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.6.3754-3757.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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