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Infection and Immunity, June 2005, p. 3778-3782, Vol. 73, No. 6
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.6.3778-3782.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Expression Cloning of Gamma Interferon-Inducing Antigens of Mycobacterium avium subsp. paratuberculosis

Reiko Nagata,* Yoshihiro Muneta, Kazuhiro Yoshihara, Yuichi Yokomizo, and Yasuyuki Mori

Immune System Section, Department of Immunology, National Institute of Animal Health, 3-1-5 Kannondai, Tsukuba, Ibaraki, Japan 305-0856

Received 16 July 2004/ Returned for modification 24 November 2004/ Accepted 23 January 2005

Three recombinant proteins, Map10, Map39, and Map41, produced based on nucleotide sequences obtained from the screening of Mycobacterium avium subsp. paratuberculosis genomic library expressed in Escherichia coli significantly elicited gamma interferon production in peripheral blood mononuclear cells from infected cattle. Two of these proteins were members of the PPE protein family.

* Corresponding author. Mailing address: Immune System Section, Department of Immunology, National Institute of Animal Health, 3-1-5 Kannondai, Tsukuba, Ibaraki, Japan 305-0856. Phone: 81-29-838-7857. Fax: 81-29-838-7880. E-mail:kikuma{at}affrc.go.jp.

Editor: J. L. Flynn

Infection and Immunity, June 2005, p. 3778-3782, Vol. 73, No. 6
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.6.3778-3782.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Rosseels, V., Marche, S., Roupie, V., Govaerts, M., Godfroid, J., Walravens, K., Huygen, K. (2006). Members of the 30- to 32-Kilodalton Mycolyl Transferase Family (Ag85) from Culture Filtrate of Mycobacterium avium subsp. paratuberculosis Are Immunodominant Th1-Type Antigens Recognized Early upon Infection in Mice and Cattle. Infect. Immun. 74: 202-212 [Abstract] [Full Text]  


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