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Infection and Immunity, June 2005, p. 3783-3786, Vol. 73, No. 6
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.6.3783-3786.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Macrophage Migration Inhibitory Factor Reduces the Growth of Virulent Mycobacterium tuberculosis in Human Macrophages

Mauro Oddo,1* Thierry Calandra,2 Richard Bucala,3 and Pascal R. A. Meylan1,2

Institute of Microbiology,1 Infectious Diseases Service, University Hospital, Lausanne, CH-1011, Switzerland,2 Department of Medicine and Pathology, Section of Rheumatology, Yale University School of Medicine, New Haven, Connecticut3

Received 1 July 2004/ Returned for modification 1 October 2004/ Accepted 11 February 2005

Macrophage migration inhibitory factor (MIF) is a key mediator of the innate immune system and plays a crucial role in the host response to bacterial infections. Its role in immunity to intracellular pathogens has not been well studied. Here, we show that MIF released by infected human macrophages inhibits the growth of virulent Mycobacterium tuberculosis.

* Corresponding author. Present address: Medical Critical Care Division, University Hospital, Lausanne, CH-1011, Switzerland. Phone: 41 21 314 1767. Fax: 41 21 314 1384. E-mail: mauro.oddo{at}chuv.hospvd.ch.

Editor: F. C. Fang

Infection and Immunity, June 2005, p. 3783-3786, Vol. 73, No. 6
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.6.3783-3786.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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