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Infection and Immunity, June 2005, p. 3790-3793, Vol. 73, No. 6
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.6.3790-3793.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Entamoeba histolytica-Secreted Products Degrade Colonic Mucin Oligosaccharides

Darcy Moncada, Kathy Keller, and Kris Chadee*

Institute of Parasitology, McGill University, Ste. Anne de Bellevue, Quebec, Canada H9X 3V9

Received 20 December 2004/ Returned for modification 27 January 2005/ Accepted 2 February 2005

Degradation of the mucus layer by Entamoeba histolytica is a prerequisite for invasion of the colonic mucosa. In this study, we demonstrate that amoeba-secreted products degrade 3H-labeled and native colonic mucin oligosaccharides independently of proteolytic activity. We conclude that E. histolytica degrades mucin oligosaccharides, which may facilitate parasite invasion of the colon.

* Corresponding author. Mailing address: Institute of Parasitology, McGill University, 21,111 Lakeshore Road, Ste. Anne de Bellevue, Quebec, Canada H9X 3V9. Phone: (514) 398-7721. Fax: (514) 398-7857. E-mail: kris.chadee{at}mcgill.ca.

Editor: W. A. Petri, Jr.

Infection and Immunity, June 2005, p. 3790-3793, Vol. 73, No. 6
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.6.3790-3793.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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  • Rawson, R. B. (2008). Intriguing parasites and intramembrane proteases. Genes Dev. 22: 1561-1566 [Abstract] [Full Text]  
  • Lidell, M. E., Moncada, D. M., Chadee, K., Hansson, G. C. (2006). Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal domain and dissolve the protective colonic mucus gel. Proc. Natl. Acad. Sci. USA 103: 9298-9303 [Abstract] [Full Text]  


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