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Infection and Immunity, June 2005, p. 3803-3805, Vol. 73, No. 6
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.6.3803-3805.2005

Contribution of Nitric Oxide to CpG-Mediated Protection against Listeria monocytogenes

Shuichi Ito, Ken J. Ishii,{dagger} Atsushi Ihata, and Dennis M. Klinman*

CBER/FDA, Bethesda, Maryland 20892

Received 18 August 2004/ Returned for modification 13 September 2004/ Accepted 10 November 2004

Immunostimulatory CpG oligodeoxynucleotides (ODN) improve host resistance to listeriae. CpG ODN trigger immune cells to produce gamma interferon and "prime" host cells to secrete nitric oxide in response to bacterial exposure. CpG treatment does not protect inducible nitric oxide synthase 2 knockout mice, indicating that NO is critical to CpG-mediated protection against listeriae.

* Corresponding author. Mailing address: Bldg. 29A, Rm. 3D10, CBER/FDA, Bethesda, MD 20892. Phone: (301) 827-1707. Fax: (301) 496-1810. E-mail: Klinman{at}CBER.FDA.GOV.

Editor: J. B. Bliska

{dagger} Present address: RIMO, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.

Infection and Immunity, June 2005, p. 3803-3805, Vol. 73, No. 6
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.6.3803-3805.2005




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  • Verthelyi, D. (2006). Female's Heightened Immune Status: Estrogen, T Cells, and Inducible Nitric Oxide Synthase in the Balance. Endocrinology 147: 659-661 [Full Text]  


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