This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ito, S. Articles by Klinman, D. M. Search for Related Content PubMed PubMed Citation Articles by Ito, S. Articles by Klinman, D. M.

 Previous Article  |  Next Article 

Infection and Immunity, June 2005, p. 3803-3805, Vol. 73, No. 6
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.6.3803-3805.2005

Contribution of Nitric Oxide to CpG-Mediated Protection against Listeria monocytogenes

Shuichi Ito, Ken J. Ishii, Atsushi Ihata, and Dennis M. Klinman^*

CBER/FDA, Bethesda, Maryland 20892

Received 18 August 2004/ Returned for modification 13 September 2004/ Accepted 10 November 2004

Immunostimulatory CpG oligodeoxynucleotides (ODN) improve host resistance to listeriae. CpG ODN trigger immune cells to produce gamma interferon and "prime" host cells to secrete nitric oxide in response to bacterial exposure. CpG treatment does not protect inducible nitric oxide synthase 2 knockout mice, indicating that NO is critical to CpG-mediated protection against listeriae.

Editor: J. B. Bliska

Present address: RIMO, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.

This article has been cited by other articles:

• Pedras-Vasconcelos, J. A., Goucher, D., Puig, M., Tonelli, L. H., Wang, V., Ito, S., Verthelyi, D. (2006). CpG oligodeoxynucleotides protect newborn mice from a lethal challenge with the neurotropic tacaribe arenavirus.. J. Immunol. 176: 4940-4949 [Abstract] [Full Text]  
• Verthelyi, D. (2006). Female's Heightened Immune Status: Estrogen, T Cells, and Inducible Nitric Oxide Synthase in the Balance. Endocrinology 147: 659-661 [Full Text]