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A rot Mutation Restores Parental Virulence to an agr-Null Staphylococcus aureus Strain in a Rabbit Model of Endocarditis

Department of Medical Microbiology & Immunology, University of Wisconsin Medical School, Madison, Wisconsin 53706,¹ LA Biomedical Research Institute at Harbor-UCLA, Torrance, California 90502,² Geffen School of Medicine at UCLA, Los Angeles, California 90024³

Received 2 September 2004/ Returned for modification 29 November 2004/ Accepted 27 January 2005

Mutations in rot restore in vitro toxin production to agr-negative strains of Staphylococcus aureus. We show that a rot mutation returns wild-type virulence to an agr mutant, as measured in experimental endocarditis infections by target organ bacterial counts. Implications of our data are discussed in terms of agr antagonist strategies.

Editor: V. J. DiRita

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