Infection and Immunity, June 2005, p. 3806-3809, Vol. 73, No. 6
0019-9567/05/$08.00+0 doi:10.1128/IAI.73.6.3806-3809.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.
A rot Mutation Restores Parental Virulence to an agr-Null Staphylococcus aureus Strain in a Rabbit Model of Endocarditis
Peter J. McNamara1* and
Arnold S. Bayer2,3
Department of Medical Microbiology & Immunology, University of Wisconsin Medical School, Madison, Wisconsin 53706,1
LA Biomedical Research Institute at Harbor-UCLA, Torrance, California 90502,2
Geffen School of Medicine at UCLA, Los Angeles, California 900243
Received 2 September 2004/
Returned for modification 29 November 2004/
Accepted 27 January 2005
Mutations in rot restore in vitro toxin production to agr-negative strains of Staphylococcus aureus. We show that a rot mutation returns wild-type virulence to an agr mutant, as measured in experimental endocarditis infections by target organ bacterial counts. Implications of our data are discussed in terms of agr antagonist strategies.
* Corresponding author. Mailing address: Department of Medical Microbiology & Immunology, 1300 University Avenue, University of Wisconsin, Biochemistry Building, Room 250, Madison, WI 53706. Phone: (608) 263-5591. Fax: (608) 262-8418. E-mail: pjmcnamara{at}facstaff.wisc.edu.
Editor: V. J. DiRita
Infection and Immunity, June 2005, p. 3806-3809, Vol. 73, No. 6
0019-9567/05/$08.00+0 doi:10.1128/IAI.73.6.3806-3809.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.
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Copyright © 2005 by the American Society for Microbiology. All rights reserved.