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Infection and Immunity, July 2005, p. 4381-4384, Vol. 73, No. 7
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.7.4381-4384.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Profile of Gene Expression in a Murine Model of Allergic Bronchopulmonary Aspergillosis

Viswanath P. Kurup,1* Raghavan Raju,2 and Pachiappan Manickam3

Allergy-Immunology Division, Medical College of Wisconsin, and Research Service, VA Medical Center, Milwaukee, Wisconsin,1 Neuromuscular Diseases Section, National Institutes of Health, Bethesda, Maryland,2 Capital Genomix, Inc., Rockville, Maryland3

Received 17 December 2004/ Returned for modification 24 January 2005/ Accepted 14 February 2005

Allergic bronchopulmonary aspergillosis (ABPA) results from the interactions of the Aspergillus allergens and immune system of the patients. We studied the gene expression profile in a mouse model of ABPA. Of the 12,000 genes studied, 1,300 genes showed enhanced expression and represent chemokine, cytokine, growth factor, signal transduction, and transmembrane receptor genes as well as genes related to arginine metabolism.

* Corresponding author. Mailing address: VA Medical Center, Research Service 151-I, 5000 West National Avenue, Milwaukee, WI 53295. Phone: (414) 384-2000, ext. 41515/41510. Fax: (414) 382-5374. E-mail: vkurup{at}mcw.edu.

Editor: T. R. Kozel

Infection and Immunity, July 2005, p. 4381-4384, Vol. 73, No. 7
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.7.4381-4384.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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