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Infection and Immunity, July 2005, p. 4385-4390, Vol. 73, No. 7
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.7.4385-4390.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Enteropathogenic Escherichia coli Type III Effectors EspG and EspG2 Disrupt the Microtubule Network of Intestinal Epithelial Cells

Robert K. Shaw,1,{dagger} Katherine Smollett,2,{dagger} Jennifer Cleary,1 Junkal Garmendia,2 Ania Straatman-Iwanowska,1 Gad Frankel,2 and Stuart Knutton1*

Institute of Child Health, University of Birmingham, Birmingham B4 6NH,1 Centre for Molecular Microbiology and Infection, Department of Biological Sciences, Imperial College London, London SW7 2AZ, United Kingdom2

Received 10 November 2004/ Returned for modification 22 December 2004/ Accepted 2 February 2005

Enteropathogenic Escherichia coli infection of intestinal epithelial cells leads to localized depletion of the microtubule cytoskeleton, an effect that is dependent on delivery of type III translocated effector proteins EspG and Orf3 (designated EspG2) to the site of depletion. Microtubule depletion involved disruption rather than displacement of microtubules.

* Corresponding author. Mailing address: Institute of Child Health, University of Birmingham, Whittall St., Birmingham B4 6NH, United Kingdom. Phone: 44 121 333 8746. Fax: 44 121 333 8701. E-mail: s.knutton{at}bham.ac.uk.

Editor: J. T. Barbieri

{dagger} Robert K. Shaw and Katherine Smollett contributed equally to this paper.

Infection and Immunity, July 2005, p. 4385-4390, Vol. 73, No. 7
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.7.4385-4390.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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