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Infection and Immunity, July 2005, p. 4395-4398, Vol. 73, No. 7
0019-9567/05/$08.00+0 doi:10.1128/IAI.73.7.4395-4398.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Role of Motility and Flagellin Glycosylation in the Pathogenesis of Pseudomonas aeruginosa Burn Wound Infections
Shiwani K. Arora,1
Alice N. Neely,2
Barbara Blair,3
Stephen Lory,3 and
Reuben Ramphal1*
Department of Medicine/Infectious Diseases, University of Florida, Gainesville, Florida, 32610,1
Shriners Hospital for Children, Cincinnati, Ohio,2
Department of Microbiology, Harvard Medical School, Boston, Massachusetts3
Received 23 February 2005/
Returned for modification 6 March 2005/
Accepted 6 March 2005
In this study, we tested the contribution of flagellar motility, flagellin structure, and its glycosylation in Pseudomonas aeruginosa using genetically defined flagellar mutants. All mutants and their parent strains were tested in a burned-mouse model of infection. Motility and glycosylation of the flagellum appear to be important determinants of flagellar-mediated virulence in this model. This is the first report where genetically defined flagellar variants of P. aeruginosa were tested in the burned-mouse model of infection.
* Corresponding author. Mailing address: Department of Medicine/Infectious Diseases, P.O. Box 100277, JHMHC, University of Florida, Gainesville, FL 32610. Phone: (352) 392-2932. Fax: (352) 392-6481. E-mail: ramphr{at}medmac.ufl.edu.
Editor: V. J. DiRita
Infection and Immunity, July 2005, p. 4395-4398, Vol. 73, No. 7
0019-9567/05/$08.00+0 doi:10.1128/IAI.73.7.4395-4398.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.
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