This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Arora, S. K.
Right arrow Articles by Ramphal, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Arora, S. K.
Right arrow Articles by Ramphal, R.

 Previous Article  |  Next Article 

Infection and Immunity, July 2005, p. 4395-4398, Vol. 73, No. 7
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.7.4395-4398.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Role of Motility and Flagellin Glycosylation in the Pathogenesis of Pseudomonas aeruginosa Burn Wound Infections

Shiwani K. Arora,1 Alice N. Neely,2 Barbara Blair,3 Stephen Lory,3 and Reuben Ramphal1*

Department of Medicine/Infectious Diseases, University of Florida, Gainesville, Florida, 32610,1 Shriners Hospital for Children, Cincinnati, Ohio,2 Department of Microbiology, Harvard Medical School, Boston, Massachusetts3

Received 23 February 2005/ Returned for modification 6 March 2005/ Accepted 6 March 2005

In this study, we tested the contribution of flagellar motility, flagellin structure, and its glycosylation in Pseudomonas aeruginosa using genetically defined flagellar mutants. All mutants and their parent strains were tested in a burned-mouse model of infection. Motility and glycosylation of the flagellum appear to be important determinants of flagellar-mediated virulence in this model. This is the first report where genetically defined flagellar variants of P. aeruginosa were tested in the burned-mouse model of infection.

* Corresponding author. Mailing address: Department of Medicine/Infectious Diseases, P.O. Box 100277, JHMHC, University of Florida, Gainesville, FL 32610. Phone: (352) 392-2932. Fax: (352) 392-6481. E-mail: ramphr{at}medmac.ufl.edu.

Editor: V. J. DiRita

Infection and Immunity, July 2005, p. 4395-4398, Vol. 73, No. 7
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.7.4395-4398.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Twine, S. M., Reid, C. W., Aubry, A., McMullin, D. R., Fulton, K. M., Austin, J., Logan, S. M. (2009). Motility and Flagellar Glycosylation in Clostridium difficile. J. Bacteriol. 191: 7050-7062 [Abstract] [Full Text]  
  • Lindhout, T., Lau, P. C. Y., Brewer, D., Lam, J. S. (2009). Truncation in the core oligosaccharide of lipopolysaccharide affects flagella-mediated motility in Pseudomonas aeruginosa PAO1 via modulation of cell surface attachment. Microbiology 155: 3449-3460 [Abstract] [Full Text]  
  • Yeung, A. T. Y., Torfs, E. C. W., Jamshidi, F., Bains, M., Wiegand, I., Hancock, R. E. W., Overhage, J. (2009). Swarming of Pseudomonas aeruginosa Is Controlled by a Broad Spectrum of Transcriptional Regulators, Including MetR. J. Bacteriol. 191: 5592-5602 [Abstract] [Full Text]  
  • Howard, S. L., Jagannathan, A., Soo, E. C., Hui, J. P. M., Aubry, A. J., Ahmed, I., Karlyshev, A., Kelly, J. F., Jones, M. A., Stevens, M. P., Logan, S. M., Wren, B. W. (2009). Campylobacter jejuni Glycosylation Island Important in Cell Charge, Legionaminic Acid Biosynthesis, and Colonization of Chickens. Infect. Immun. 77: 2544-2556 [Abstract] [Full Text]  
  • Redondo-Nieto, M., Lloret, J., Larenas, J., Barahona, E., Navazo, A., Martinez-Granero, F., Capdevila, S., Rivilla, R., Martin, M. (2008). Transcriptional Organization of the Region Encoding the Synthesis of the Flagellar Filament in Pseudomonas fluorescens. J. Bacteriol. 190: 4106-4109 [Abstract] [Full Text]  
  • Blohmke, C. J., Victor, R. E., Hirschfeld, A. F., Elias, I. M., Hancock, D. G., Lane, C. R., Davidson, A. G. F., Wilcox, P. G., Smith, K. D., Overhage, J., Hancock, R. E. W., Turvey, S. E. (2008). Innate Immunity Mediated by TLR5 as a Novel Antiinflammatory Target for Cystic Fibrosis Lung Disease. J. Immunol. 180: 7764-7773 [Abstract] [Full Text]  
  • Taguchi, F., Shibata, S., Suzuki, T., Ogawa, Y., Aizawa, S.-I., Takeuchi, K., Ichinose, Y. (2008). Effects of Glycosylation on Swimming Ability and Flagellar Polymorphic Transformation in Pseudomonas syringae pv. tabaci 6605. J. Bacteriol. 190: 764-768 [Abstract] [Full Text]  
  • Takeuchi, K., Ono, H., Yoshida, M., Ishii, T., Katoh, E., Taguchi, F., Miki, R., Murata, K., Kaku, H., Ichinose, Y. (2007). Flagellin Glycans from Two Pathovars of Pseudomonas syringae Contain Rhamnose in D and L Configurations in Different Ratios and Modified 4-Amino-4,6-Dideoxyglucose. J. Bacteriol. 189: 6945-6956 [Abstract] [Full Text]  
  • Rawls, J. F., Mahowald, M. A., Goodman, A. L., Trent, C. M., Gordon, J. I. (2007). In vivo imaging and genetic analysis link bacterial motility and symbiosis in the zebrafish gut. Proc. Natl. Acad. Sci. USA 104: 7622-7627 [Abstract] [Full Text]  
  • Shen, A., Kamp, H. D., Grundling, A., Higgins, D. E. (2006). A bifunctional O-GlcNAc transferase governs flagellar motility through anti-repression. Genes Dev. 20: 3283-3295 [Abstract] [Full Text]  
  • Aas, F. E., Egge-Jacobsen, W., Winther-Larsen, H. C., Lovold, C., Hitchen, P. G., Dell, A., Koomey, M. (2006). Neisseria gonorrhoeae Type IV Pili Undergo Multisite, Hierarchical Modifications with Phosphoethanolamine and Phosphocholine Requiring an Enzyme Structurally Related to Lipopolysaccharide Phosphoethanolamine Transferases. J. Biol. Chem. 281: 27712-27723 [Abstract] [Full Text]  
  • McNally, D. J., Hui, J. P. M., Aubry, A. J., Mui, K. K. K., Guerry, P., Brisson, J.-R., Logan, S. M., Soo, E. C. (2006). Functional Characterization of the Flagellar Glycosylation Locus in Campylobacter jejuni 81-176 Using a Focused Metabolomics Approach. J. Biol. Chem. 281: 18489-18498 [Abstract] [Full Text]  
  • Verma, A., Schirm, M., Arora, S. K., Thibault, P., Logan, S. M., Ramphal, R. (2006). Glycosylation of b-Type Flagellin of Pseudomonas aeruginosa: Structural and Genetic Basis.. J. Bacteriol. 188: 4395-4403 [Abstract] [Full Text]  
  • Logan, S. M. (2006). Flagellar glycosylation - a new component of the motility repertoire?. Microbiology 152: 1249-1262 [Abstract] [Full Text]  
  • Schoenhofen, I. C., Lunin, V. V., Julien, J.-P., Li, Y., Ajamian, E., Matte, A., Cygler, M., Brisson, J.-R., Aubry, A., Logan, S. M., Bhatia, S., Wakarchuk, W. W., Young, N. M. (2006). Structural and Functional Characterization of PseC, an Aminotransferase Involved in the Biosynthesis of Pseudaminic Acid, an Essential Flagellar Modification in Helicobacter pylori. J. Biol. Chem. 281: 8907-8916 [Abstract] [Full Text]  
  • Smedley, J. G. III, Jewell, E., Roguskie, J., Horzempa, J., Syboldt, A., Stolz, D. B., Castric, P. (2005). Influence of Pilin Glycosylation on Pseudomonas aeruginosa 1244 Pilus Function. Infect. Immun. 73: 7922-7931 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»