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Infection and Immunity, July 2005, p. 4399-4403, Vol. 73, No. 7
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.7.4399-4403.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

KatA, the Major Catalase, Is Critical for Osmoprotection and Virulence in Pseudomonas aeruginosa PA14

Ji-Sun Lee, Yun-Jeong Heo, Jeong K. Lee, and You-Hee Cho*

Department of Life Science, Sogang University, Seoul 121-742, Korea

Received 3 November 2004/ Returned for modification 7 January 2005/ Accepted 24 February 2005

We demonstrate that among the three monofunctional catalases of Pseudomonas aeruginosa PA14, KatA and, to a lesser extent, KatB, but not KatE, are required for resistance to peroxide and osmotic stresses. KatA is crucial for adaptation to H2O2 stress and full virulence in both Drosophila melanogaster and mice. This dismantling of catalase roles represents a specialized catalytic system primarily involving KatA in responses to adverse environmental conditions.

* Corresponding author. Mailing address: Department of Life Science, Sogang University, Seoul 121-742, Korea. Phone: 82-2-705-8793. Fax: 82-2-704-3601. E-mail: youhee{at}sogang.ac.kr.

Editor: V. J. DiRita

Infection and Immunity, July 2005, p. 4399-4403, Vol. 73, No. 7
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.7.4399-4403.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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