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Infection and Immunity, July 2005, p. 4410-4413, Vol. 73, No. 7
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.7.4410-4413.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Involvement of Listeria monocytogenes Phosphatidylinositol-Specific Phospholipase C and Host Protein Kinase C in Permeabilization of the Macrophage Phagosome

Mathilde A. Poussin and Howard Goldfine*

Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6076

Received 11 June 2004/ Returned for modification 20 July 2004/ Accepted 22 February 2005

We have previously shown that phosphatidylinositol-specific phospholipase C (PI-PLC) produced by Listeria monocytogenes activates a host protein kinase C (PKC) cascade which promotes escape of the bacterium from a macrophage-like cell phagosome. Here, we provide evidence linking bacterial PI-PLC and host PKC ß to phagosome permeabilization, which precedes escape.

* Corresponding author. Mailing address: Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6076. Phone: (215) 898-6384. Fax: (215) 898-9557. E-mail: goldfinh{at}mail.med.upenn.edu.

Editor: J. B. Bliska

Infection and Immunity, July 2005, p. 4410-4413, Vol. 73, No. 7
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.7.4410-4413.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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