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Infection and Immunity, July 2005, p. 4423-4426, Vol. 73, No. 7
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.7.4423-4426.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Cross-Recognition of N-Formylmethionine Peptides Is a General Characteristic of H2-M3-Restricted CD8+ T Cells

Alexander Ploss,1,2 An Tran,1 Ewa Menet,1 Ingrid Leiner,1 and Eric G. Pamer1*

Infectious Diseases Service, Department of Medicine and Laboratory of Antimicrobial Immunity, Immunology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021,1 Immunology Program, Weill Graduate School of Medical Sciences of Cornell University, New York, New York 100212

Received 12 January 2005/ Returned for modification 1 February 2005/ Accepted 17 February 2005

H2-M3-restricted CD8+ T cells can exhibit cross-reactivity to different bacterially derived N-formylmethionine peptides. The extent of this promiscuity is unclear. We deleted the nonredundant fMIVTLF epitope and found that Listeria monocytogenes still primed fMIVTLF-specific T cells. Thus, cross-reactivity appears to be a more general characteristic of H2-M3-restricted T cells.

* Corresponding author. Mailing address: Infectious Diseases Service, Department of Medicine and Laboratory of Antimicrobial Immunity, Immunology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021. Phone: (212) 639-7809. Fax: (212) 717-3021. E-mail: pamere{at}mskcc.org.

Editor: F. C. Fang

Infection and Immunity, July 2005, p. 4423-4426, Vol. 73, No. 7
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.7.4423-4426.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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  • Xu, H., Chun, T., Choi, H.-J., Wang, B., Wang, C.-R. (2006). Impaired response to Listeria in H2-M3-deficient mice reveals a nonredundant role of MHC class Ib-specific T cells in host defense. JEM 203: 449-459 [Abstract] [Full Text]  


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