This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hu, L.
Right arrow Articles by Hickey, T. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hu, L.
Right arrow Articles by Hickey, T. E.

 Previous Article  |  Next Article 

Infection and Immunity, July 2005, p. 4437-4440, Vol. 73, No. 7
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.7.4437-4440.2005

Campylobacter jejuni Induces Secretion of Proinflammatory Chemokines from Human Intestinal Epithelial Cells

Lan Hu{dagger} and Thomas E. Hickey*

Naval Medical Research Center, Silver Spring, Maryland

Received 17 November 2004/ Returned for modification 6 December 2004/ Accepted 2 February 2005

Campylobacter jejuni is a common cause of diarrhea in humans. While the pathogenic mechanisms of C. jejuni are not completely understood, host inflammatory responses are thought to be contributing factors. In this report, C. jejuni 81-176 is shown to up-regulate chemokines essential to inflammatory responses. Growth-related oncogene {alpha} (GRO{alpha}), GRO{gamma}, macrophage inflammatory protein 1, monocyte chemoattractant protein 1 (MCP-1), and gamma interferon-inducible protein 10 ({gamma}IP-10) mRNA transcription in INT-407 cells was enhanced within 4 h of bacterial exposure. Infection with viable campylobacters was necessary for sustained chemokine transcription and was NF-{kappa}B dependent. GRO{alpha}, {gamma}IP-10, and MCP-1 chemokine secretions were confirmed by immunological assays.

* Corresponding author. Mailing address: Enterics Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910-7500. Phone: (301) 319-7579. Fax: (301) 319-7679. E-mail: hickeyt{at}nmrc.navy.mil.

Editor: J. T. Barbieri

{dagger} Present address: Enterics and STD Laboratory, CBER, FDA, 29 Lincoln Drive, Room 424, Bethesda, MD 20892-4555.

Infection and Immunity, July 2005, p. 4437-4440, Vol. 73, No. 7
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.7.4437-4440.2005




This article has been cited by other articles:

  • Stewart-Tull, D. E. S., Coote, J. G., Thompson, D. H, Candlish, D., Wardlaw, A. C., Candlish, A. (2009). Virulence spectra of typed strains of Campylobacter jejuni from different sources: a blinded in vivo study. J Med Microbiol 58: 546-553 [Abstract] [Full Text]  
  • Friis, L. M., Keelan, M., Taylor, D. E. (2009). Campylobacter jejuni Drives MyD88-Independent Interleukin-6 Secretion via Toll-Like Receptor 2. Infect. Immun. 77: 1553-1560 [Abstract] [Full Text]  
  • Zheng, J., Meng, J., Zhao, S., Singh, R., Song, W. (2008). Campylobacter-Induced Interleukin-8 Secretion in Polarized Human Intestinal Epithelial Cells Requires Campylobacter-Secreted Cytolethal Distending Toxin- and Toll-Like Receptor-Mediated Activation of NF-{kappa}B. Infect. Immun. 76: 4498-4508 [Abstract] [Full Text]  
  • Janssen, R., Krogfelt, K. A., Cawthraw, S. A., van Pelt, W., Wagenaar, J. A., Owen, R. J. (2008). Host-Pathogen Interactions in Campylobacter Infections: the Host Perspective. Clin. Microbiol. Rev. 21: 505-518 [Abstract] [Full Text]  
  • Yoder, J. M., Aslam, R. U., Mantis, N. J. (2007). Evidence for Widespread Epithelial Damage and Coincident Production of Monocyte Chemotactic Protein 1 in a Murine Model of Intestinal Ricin Intoxication. Infect. Immun. 75: 1745-1750 [Abstract] [Full Text]  
  • MacCallum, A. J., Harris, D., Haddock, G., Everest, P. H. (2006). Campylobacter jejuni-infected human epithelial cell lines vary in their ability to secrete interleukin-8 compared to in vitro-infected primary human intestinal tissue. Microbiology 152: 3661-3665 [Abstract] [Full Text]  
  • Chen, M. L., Ge, Z., Fox, J. G., Schauer, D. B. (2006). Disruption of Tight Junctions and Induction of Proinflammatory Cytokine Responses in Colonic Epithelial Cells by Campylobacter jejuni. Infect. Immun. 74: 6581-6589 [Abstract] [Full Text]  
  • Long, K. Z., Santos, J. I., Estrada Garcia, T., Haas, M., Firestone, M., Bhagwat, J., DuPont, H. L., Hertzmark, E., Rosado, J. L., Nanthakumar, N. N. (2006). Vitamin A Supplementation Reduces the Monocyte Chemoattractant Protein-1 Intestinal Immune Response of Mexican Children. J. Nutr. 136: 2600-2605 [Abstract] [Full Text]  
  • Johanesen, P. A., Dwinell, M. B. (2006). Flagellin-Independent Regulation of Chemokine Host Defense in Campylobacter jejuni-Infected Intestinal Epithelium.. Infect. Immun. 74: 3437-3447 [Abstract] [Full Text]  
  • Hu, L., Bray, M. D., Osorio, M., Kopecko, D. J. (2006). Campylobacter jejuni Induces Maturation and Cytokine Production in Human Dendritic Cells.. Infect. Immun. 74: 2697-2705 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»