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Infection and Immunity, July 2005, p. 4437-4440, Vol. 73, No. 7
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.7.4437-4440.2005

Campylobacter jejuni Induces Secretion of Proinflammatory Chemokines from Human Intestinal Epithelial Cells

Lan Hu{dagger} and Thomas E. Hickey*

Naval Medical Research Center, Silver Spring, Maryland

Received 17 November 2004/ Returned for modification 6 December 2004/ Accepted 2 February 2005

Campylobacter jejuni is a common cause of diarrhea in humans. While the pathogenic mechanisms of C. jejuni are not completely understood, host inflammatory responses are thought to be contributing factors. In this report, C. jejuni 81-176 is shown to up-regulate chemokines essential to inflammatory responses. Growth-related oncogene {alpha} (GRO{alpha}), GRO{gamma}, macrophage inflammatory protein 1, monocyte chemoattractant protein 1 (MCP-1), and gamma interferon-inducible protein 10 ({gamma}IP-10) mRNA transcription in INT-407 cells was enhanced within 4 h of bacterial exposure. Infection with viable campylobacters was necessary for sustained chemokine transcription and was NF-{kappa}B dependent. GRO{alpha}, {gamma}IP-10, and MCP-1 chemokine secretions were confirmed by immunological assays.

* Corresponding author. Mailing address: Enterics Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910-7500. Phone: (301) 319-7579. Fax: (301) 319-7679. E-mail: hickeyt{at}nmrc.navy.mil.

Editor: J. T. Barbieri

{dagger} Present address: Enterics and STD Laboratory, CBER, FDA, 29 Lincoln Drive, Room 424, Bethesda, MD 20892-4555.

Infection and Immunity, July 2005, p. 4437-4440, Vol. 73, No. 7
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.7.4437-4440.2005




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