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Infection and Immunity, July 2005, p. 4445-4450, Vol. 73, No. 7
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.7.4445-4450.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Genome Scale Identification of Treponema pallidum Antigens

Matthew McKevitt,1 Mary Beth Brinkman,1 Melanie McLoughlin,2 Carla Perez,1 Jerrilyn K. Howell,2 George M. Weinstock,4 Steven J. Norris,2,3 and Timothy Palzkill1*

Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030,1 Department of Pathology and Laboratory Medicine,2 Department of Microbiology and Molecular Genetics, University of Texas—Houston Medical School, 6431 Fannin Street, Houston, Texas 77030,3 Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas4

Received 10 February 2005/ Accepted 18 February 2005

Antibody responses for 882 of the 1,039 proteins in the proteome of Treponema pallidum were examined. Sera collected from infected rabbits were used to systematically identify 106 antigenic proteins, including 22 previously identified antigens and 84 novel antigens. Additionally, sera collected from rabbits throughout the course of infection demonstrated a progression in the breadth and intensity of humoral immunoreactivity against a representative panel of T. pallidum antigens.

* Corresponding author. Mailing address: Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030. Phone: (713) 798-5609. Fax: (713) 798-7375. E-mail: timothyp{at}bcm.tmc.edu.

Infection and Immunity, July 2005, p. 4445-4450, Vol. 73, No. 7
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.7.4445-4450.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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  • Brinkman, M. B., McGill, M. A., Pettersson, J., Rogers, A., Matejkova, P., Smajs, D., Weinstock, G. M., Norris, S. J., Palzkill, T. (2008). A Novel Treponema pallidum Antigen, TP0136, Is an Outer Membrane Protein That Binds Human Fibronectin. Infect. Immun. 76: 1848-1857 [Abstract] [Full Text]  
  • Strouhal, M., Smajs, D., Matejkova, P., Sodergren, E., Amin, A. G., Howell, J. K., Norris, S. J., Weinstock, G. M. (2007). Genome Differences between Treponema pallidum subsp. pallidum Strain Nichols and T. paraluiscuniculi Strain Cuniculi A. Infect. Immun. 75: 5859-5866 [Abstract] [Full Text]  
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