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Infection and Immunity, July 2005, p. 4451-4453, Vol. 73, No. 7
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.7.4451-4453.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Structural Diversity of Streptokinase and Activation of Human Plasminogen

Sergio Lizano1* and Kenneth H. Johnston2

Department of Microbiology and Immunology, New York Medical College, Valhalla, New York 10595,1 Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, Louisiana 701122

Received 30 January 2005/ Accepted 8 February 2005

The ß domain of streptokinase is required for plasminogen activation and contains a region of sequence diversity associated with infection and disease in group A streptococci. We report that mutagenesis of this polymorphic region does not alter plasminogen activation, which suggests an alternative function for this molecular motif in streptococcal disease.

* Corresponding author. Mailing address: Dept. of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595. Phone: (914) 594-4180. Fax: (914) 594-4176. E-mail: sergio_lizano{at}nymc.edu.

Editor: V. J. DiRita

Infection and Immunity, July 2005, p. 4451-4453, Vol. 73, No. 7
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.7.4451-4453.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Aneja, R., Datt, M., Singh, B., Kumar, S., Sahni, G. (2009). Identification of a New Exosite Involved in Catalytic Turnover by the Streptokinase-Plasmin Activator Complex during Human Plasminogen Activation. J. Biol. Chem. 284: 32642-32650 [Abstract] [Full Text]  
  • McArthur, J. D., McKay, F. C., Ramachandran, V., Shyam, P., Cork, A. J., Sanderson-Smith, M. L., Cole, J. N., Ringdahl, U., Sjobring, U., Ranson, M., Walker, M. J. (2008). Allelic variants of streptokinase from Streptococcus pyogenes display functional differences in plasminogen activation. FASEB J. 22: 3146-3153 [Abstract] [Full Text]  
  • Lizano, S., Luo, F., Bessen, D. E. (2007). Role of Streptococcal T Antigens in Superficial Skin Infection. J. Bacteriol. 189: 1426-1434 [Abstract] [Full Text]  


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