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Infection and Immunity, August 2005, p. 5204-5207, Vol. 73, No. 8
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.8.5204-5207.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Virulence Comparisons of Aspergillus nidulans Mutants Are Confounded by the Inflammatory Response of p47phox–/– Mice

Elaine Bignell,* Susana Negrete-Urtasun, Ana Maria Calcagno, Herbert N. Arst Jr., Tom Rogers,{dagger} and Ken Haynes

Department of Infectious Diseases, Imperial College London, London W12 0NN, United Kingdom

Received 5 January 2005/ Returned for modification 26 January 2005/ Accepted 1 April 2005

While investigating the requirement for phagosomal alkalinization in the host defense against pulmonary aspergillosis, we observed high morbidity of p47phox–/– mice infected with pH-insensitive Aspergillus nidulans mutants despite a paucity of fungal growth. Fatal infection also resulted from a normally avirulent p-aminobenzoate auxotroph. This demonstrates that p47phox–/– murine immunity contributes significantly to A. nidulans lethality. These data have wider implications for microbial virulence studies with p47phox–/– mice.

* Corresponding author. Mailing address: Department of Infectious Diseases, Imperial College London, Du Cane Road, London W12 0NN, United Kingdom. Phone: 44 20 8383 1242. Fax: 44 20 8383 3394. E-mail: e.bignell{at}imperial.ac.uk.

Editor: T. R. Kozel

{dagger} Present address: Department of Clinical Microbiology, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland.

Infection and Immunity, August 2005, p. 5204-5207, Vol. 73, No. 8
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.8.5204-5207.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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