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Infection and Immunity, August 2005, p. 5208-5211, Vol. 73, No. 8
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.8.5208-5211.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Identification of Variant-Specific Surface Proteins in Giardia muris Trophozoites

Andrea S. Ropolo, Alicia Saura, Pedro G. Carranza, and Hugo D. Lujan*

Cátedra de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad Nacional de Córdoba, CP 5000 Córdoba, Argentina

Received 15 October 2004/ Returned for modification 22 November 2004/ Accepted 3 March 2005

Giardia lamblia undergoes antigenic variation, a process that might allow the parasite to evade the host's immune response and adapt to different environments. Here we show that Giardia muris, a related species that naturally infects rodents, possesses multiple variant-specific surface proteins (VSPs) and expresses VSPs on its surface, suggesting that it undergoes antigenic variation similar to that of G. lamblia.

* Corresponding author. Mailing address: Cátedra de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad Nacional de Córdoba, Haya de la Torre S/N, Pabellón Argentina 2do piso, Ciudad Universitaria, CP 5000 Córdoba, Argentina. Phone: 54-351-4333024, ext. 108. Fax: 54-351-4333072. E-mail: hlujan{at}biomed.uncor.edu.

Editor: W. A. Petri, Jr.

Infection and Immunity, August 2005, p. 5208-5211, Vol. 73, No. 8
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.8.5208-5211.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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