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Infection and Immunity, August 2005, p. 5217-5221, Vol. 73, No. 8
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.8.5217-5221.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Selective Capture of Salmonella enterica Serovar Typhi Genes Expressed in Macrophages That Are Absent from the Salmonella enterica Serovar Typhimurium Genome

Sébastien P. Faucher,1 Roy Curtiss III,2,{dagger} and France Daigle1,2*

Department of Microbiology and Immunology, University of Montreal, Montréal, Québec, Canada,1 Department of Biology, Washington University, St. Louis, Missouri2

Received 10 January 2005/ Returned for modification 16 March 2005/ Accepted 30 March 2005

Thirty-six Salmonella enterica serovar Typhi-specific genes, absent from the Salmonella enterica serovar Typhimurium genome, that were expressed in human macrophages were identified by selective capture of transcribed sequences. These genes are located on 15 unique loci of the serovar Typhi genome, including Salmonella pathogenicity islands (SPI-7, SPI-8, and SPI-10) and bacteriophages (ST15, ST18, and ST35).


* Corresponding author. Mailing address: Department of Microbiology and Immunology, University of Montreal, C.P. 6128 Succursale Centre-ville, Montréal, Québec, Canada H3C 3J7. Phone: (514) 343-7396. Fax: (514) 343-5701. E-mail: france.daigle{at}umontreal.ca.

Editor: J. N. Weiser

{dagger} Present address: Biodesign Institute, Arizona State University, Tempe, Ariz.


Infection and Immunity, August 2005, p. 5217-5221, Vol. 73, No. 8
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.8.5217-5221.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.




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