IAI FigSearch
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dileepan, T.
Right arrow Articles by Maheswaran, S. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dileepan, T.
Right arrow Articles by Maheswaran, S. K.

 Previous Article  |  Next Article 

Infection and Immunity, August 2005, p. 5233-5237, Vol. 73, No. 8
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.8.5233-5237.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Mapping of the Binding Site for Mannheimia haemolytica Leukotoxin within Bovine CD18

T. Dileepan, M. S. Kannan, B. Walcheck, P. Thumbikat, and S. K. Maheswaran*

Department of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, Minnesota

Received 9 November 2004/ Returned for modification 30 November 2004/ Accepted 4 April 2005

To map the site involved in Mannheimia haemolytica leukotoxin (LktA) binding and biological activity within bovine CD18, bovine x human CD18 chimeric constructs were generated and coexpressed with bovine CD11a in K562 cells. Studies with the chimeric leukocyte function-associated antigen 1 transductants demonstrate that the site required for LktA binding and biological effects resides within amino acid residues 500 and 600 of the extracellular region of bovine CD18.

* Corresponding author. Mailing address: Department of Veterinary and Biomedical Sciences, University of Minnesota, 1971 Commonwealth Avenue, St. Paul, MN 55108. Phone: (612) 625-6264. Fax: (612) 625-5203. E-mail: mahes001{at}umn.edu.

Editor: J. T. Barbieri

Infection and Immunity, August 2005, p. 5233-5237, Vol. 73, No. 8
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.8.5233-5237.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
J. Bacteriol. J. Virol. Eukaryot. Cell
Microbiol. Mol. Biol. Rev. Clin. Vaccine Immunol. All ASM Journals

Copyright © 2005 by the American Society for Microbiology. All rights reserved.