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Infection and Immunity, August 2005, p. 5241-5244, Vol. 73, No. 8
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.8.5241-5244.2005

Staphylococcus aureus Infection of Epidermal Keratinocytes Promotes Expression of Innate Antimicrobial Peptides

Medical Research Service of the Veterans Affairs Puget Sound Health Care System, Seattle, Washington,¹ Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington²

Received 21 October 2004/ Returned for modification 26 January 2005/ Accepted 5 April 2005

Keratinocytes upregulate expression of endogenous antimicrobial peptides in response to inflammatory stimuli. We show that both viable and heat-inactivated Staphylococcus aureus and lipoteichoic acid differentially alter expression of these peptides upon contact with human keratinocytes. The findings indicate a diversity of staphylococcal factors involved in upregulation of antimicrobial peptide expression in cutaneous epithelia.

Editor: V. J. DiRita

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