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Infection and Immunity, September 2005, p. 6143-6146, Vol. 73, No. 9
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.9.6143-6146.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Paneth Cells and Antibacterial Host Defense in Neonatal Small Intestine

Michael P. Sherman,1* Stephen H. Bennett,1 Freda F. Y. Hwang,1 Jan Sherman,2,{dagger} and Charles L. Bevins3

Department of Pediatrics, University of California, Davis,1 Department of Family Health Care, University of California, San Francisco,2 Department of Microbiology and Immunology, University of California, Davis, California3

Received 5 January 2005/ Returned for modification 22 February 2005/ Accepted 5 May 2005

Paneth cells are specialized epithelia in the small bowel that secrete antimicrobial proteins. Paneth cells are vital to the innate immunity of the small bowel in adult mammals, but their role during neonatal infection of the small bowel is not well established. Dithizone selectively damages Paneth cells, and when dithizone-treated newborn rats are infected enterally with Escherichia coli, the numbers of E. coli cells in their jejunal and ileal lavage fluid are significantly increased compared to controls. The data support that Paneth cells are necessary for neonatal antibacterial defense.

* Corresponding author. Present address: Southern Illinois University School of Medicine, Neonatology, Room 4W 16, 415 North 9th Street, Springfield, IL 62769. Phone: (217) 544-6464, ext. 30460. E-mail: mpshermanMD{at}aol.com.

Editor: A. D. O'Brien

{dagger} Present address: University of Missouri, Saint Louis, College of Nursing, One University Boulevard, Saint Louis, MO 63121.

Infection and Immunity, September 2005, p. 6143-6146, Vol. 73, No. 9
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.9.6143-6146.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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