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Infection and Immunity, September 2005, p. 6147-6150, Vol. 73, No. 9
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.9.6147-6150.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Synthesis of Melanin Pigment by Candida albicans In Vitro and during Infection

Rachael Morris-Jones,1* Beatriz L. Gomez,1 Soraya Diez,1 Martha Uran,2 Stephen D. Morris-Jones,3 Arturo Casadevall,4 Joshua D. Nosanchuk,5 and Andrew J. Hamilton1

Dermatology Department, St. John's Institute of Dermatology, Guy's Hospital, Guy's, Kings, and St. Thomas' Medical Schools, London, United Kingdom,1 Corporación para Investigaciones Biológicas, Medellin, Colombia,2 Department of Microbiology,University College Hospital, London, United Kingdom,3 Department of Microbiology & Immunology,4 Department of Medicine, Albert Einstein College of Medicine, Bronx, New York5

Received 7 February 2005/ Returned for modification 15 March 2005/ Accepted 4 May 2005

Melanins are implicated in the pathogenesis of several important human diseases. This study confirmed the presence of melanin particles in Candida albicans in vitro and during infection. Dark particles were isolated from the digestion of C. albicans cultures and from infected tissue, as established by electron microscopy and immunofluorescence techniques.

* Corresponding author. Mailing address: St. John's Institute of Dermatology, St. Thomas' Hospital, London SE1 9RT, United Kingdom. Phone: 02079554663. Fax: 011 44 2079552103. E-mail: themojos{at}boltblue.com.

Editor: T. R. Kozel

Infection and Immunity, September 2005, p. 6147-6150, Vol. 73, No. 9
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.9.6147-6150.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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