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Infection and Immunity, September 2005, p. 6151-6153, Vol. 73, No. 9
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.9.6151-6153.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

The Mycobacterium tuberculosis ESAT-6 Homologue in Listeria monocytogenes Is Dispensable for Growth In Vitro and In Vivo

Sing Sing Way1* and Christopher B. Wilson1,2

Departments of Pediatrics,1 Immunology, University of Washington School of Medicine, Seattle, Washington 981952

Received 25 February 2005/ Returned for modification 19 April 2005/ Accepted 9 May 2005

ESAT-6 is a virulence determinant in Mycobacterium tuberculosis and a member of a conserved group of proteins in a variety of other bacteria. A targeted deletion of the homologous gene in Listeria was generated, and in contrast to that observed for mycobacteria, this locus was not required for Listeria virulence.

* Corresponding author. Mailing address: Department of Pediatrics, University of Washington School of Medicine, 1959 NE Pacific Street, Box 357650, Seattle, WA 98195. Phone: (206) 221-2819. Fax: (206) 543-1013. E-mail: singsing{at}u.washington.edu.

Editor: J. L. Flynn

Infection and Immunity, September 2005, p. 6151-6153, Vol. 73, No. 9
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.9.6151-6153.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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