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Infection and Immunity, September 2005, p. 6154-6156, Vol. 73, No. 9
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.9.6154-6156.2005

CpG Oligodeoxynucleotides Increase the Susceptibility of Normal Mice to Infection by Candida albicans

Shuichi Ito,1 Joao Pedras-Vasconcelos,2 and Dennis M. Klinman1*

Section of Retroviral Immunology,1 Division of Therapeutic Proteins, CBER/FDA, Bethesda, Maryland 208922

Received 28 February 2005/ Returned for modification 4 April 2005/ Accepted 19 April 2005

Synthetic oligodeoxynucleotides containing CpG motifs trigger an innate immune response that typically increases host resistance to infection. Yet CpG treatment reduces the resistance of normal mice to Candida albicans infection. This effect is mediated by CpG-induced interleukin-12, indicating that CpG-dependent cytokine production may have adverse consequences for the host.

* Corresponding author. Mailing address: Building 29A, Room 3D10, CBER/FDA, Bethesda, MD 20892. Phone: (301) 827-1707. Fax: (301) 496-1810. E-mail: Klinman{at}CBER.FDA.gov.

Editor: T. R. Kozel

Infection and Immunity, September 2005, p. 6154-6156, Vol. 73, No. 9
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.9.6154-6156.2005




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