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Infection and Immunity, September 2005, p. 6165-6168, Vol. 73, No. 9
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.9.6165-6168.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Horizontally Acquired Genes for Purine Salvage in Borrelia spp. Causing Relapsing Fever

Alan G. Barbour,* Adrienne D. Putteet-Driver, and Jonas Bunikis

Departments of Microbiology and Molecular Genetics and Medicine, University of California Irvine, Irvine, California 92697-4025

Received 13 January 2005/ Returned for modification 6 March 2005/ Accepted 7 April 2005

Unlike Borrelia burgdorferi, the relapsing fever agent Borrelia hermsii and the related Borrelia miyamotoi had purA and purB genes of the purine salvage pathway. These were located among the rRNA genes. Phylogenetic analysis indicated that these genes had a different evolutionary history than those of orthologs in other spirochetes.

* Corresponding author. Mailing address: Pacific-Southwest Center, 346 Hewitt Hall, University of California Irvine, Irvine, CA 92697-4025. Phone: (949) 824-5626. Fax: (949) 824-6452. E-mail: abarbour{at}uci.edu.

Editor: V. J. DiRita

Infection and Immunity, September 2005, p. 6165-6168, Vol. 73, No. 9
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.9.6165-6168.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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  • Pettersson, J., Schrumpf, M. E., Raffel, S. J., Porcella, S. F., Guyard, C., Lawrence, K., Gherardini, F. C., Schwan, T. G. (2007). Purine Salvage Pathways among Borrelia Species. Infect. Immun. 75: 3877-3884 [Abstract] [Full Text]  
  • Zhong, J., Skouloubris, S., Dai, Q., Myllykallio, H., Barbour, A. G. (2006). Function and Evolution of Plasmid-Borne Genes for Pyrimidine Biosynthesis in Borrelia spp.. J. Bacteriol. 188: 909-918 [Abstract] [Full Text]  


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