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Infection and Immunity, September 2005, p. 6169-6173, Vol. 73, No. 9
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.9.6169-6173.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Gene Expression Profile Analysis of Porphyromonas gingivalis during Invasion of Human Coronary Artery Endothelial Cells

Paulo H. Rodrigues and Ann Progulske-Fox*

Department of Oral Biology, College of Dentistry and Center for Molecular Microbiology, University of Florida, Gainesville, Florida 32610

Received 26 October 2004/ Returned for modification 18 November 2004/ Accepted 20 April 2005

Microarrays were used to identify genes of Porphyromonas gingivalis W83 differentially expressed during invasion of primary human coronary artery endothelial cells. Analyses of microarray images indicated that 62 genes were differentially regulated. Of these, 11 genes were up-regulated and 51 were down-regulated. The differential expression of 16 selected genes was confirmed by real-time PCR.

* Corresponding author. Mailing address: Department of Oral Biology, University of Florida, P.O. Box 100424, Gainesville, FL 32610-0424. Phone: (352) 846-0770. Fax: (352) 392-2361. E-mail: apfox{at}dental.ufl.edu.

Editor: J. B. Bliska

Infection and Immunity, September 2005, p. 6169-6173, Vol. 73, No. 9
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.9.6169-6173.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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