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Infection and Immunity, September 2005, p. 6174-6178, Vol. 73, No. 9
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.9.6174-6178.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Analysis of Cellular Phenotypes That Mediate Genetic Resistance to Tuberculosis Using a Radiation Bone Marrow Chimera Approach

Konstantin B. Majorov, Evgeny B. Eruslanov, Elvira I. Rubakova, Tatiana K. Kondratieva, and Alexander S. Apt*

Laboratory for Immunogenetics, Central Institute for Tuberculosis, Yauza alley 2, Moscow 107564, Russia

Received 27 January 2005/ Returned for modification 2 March 2005/ Accepted 24 April 2005

Adoptive transfer of bone marrow cells from tuberculosis-resistant (I/St x A/Sn)F1 donor mice into lethally irradiated susceptible I/St recipients changed their phenotype following infection with virulent Mycobacterium tuberculosis. Compared to I/St->I/St control animals, F1->I/St chimeras demonstrated (i) prolonged survival time, (ii) increased antimycobacterial function of lung macrophages, (iii) elevated gamma interferon production by lung cells, and (iv) decreased infiltration of the lungs with CD4+ and CD8+ T cells and Ly-6G+ neutrophils.

* Corresponding author. Mailing address: Laboratory for Immunogenetics, Central Institute for Tuberculosis, Yauza alley 2, Moscow 107564, Russia. Phone: 7095 268 78 10. Fax: 7095 963 80 00. E-mail: asapt{at}aha.ru.

Editor: J. L. Flynn

Infection and Immunity, September 2005, p. 6174-6178, Vol. 73, No. 9
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.9.6174-6178.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Marquis, J.-F., LaCourse, R., Ryan, L., North, R. J., Gros, P. (2009). Genetic and Functional Characterization of the Mouse Trl3 Locus in Defense against Tuberculosis. J. Immunol. 182: 3757-3767 [Abstract] [Full Text]  
  • Orlova, M. O., Majorov, K. B., Lyadova, I. V., Eruslanov, E. B., M'lan, C. E., Greenwood, C. M. T., Schurr, E., Apt, A. S. (2006). Constitutive differences in gene expression profiles parallel genetic patterns of susceptibility to tuberculosis in mice.. Infect. Immun. 74: 3668-3672 [Abstract] [Full Text]  


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