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Infection and Immunity, September 2005, p. 6183-6186, Vol. 73, No. 9
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.9.6183-6186.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

The Protective Effect of Antibody in Immunity to Murine Chlamydial Genital Tract Reinfection Is Independent of Immunoglobulin A

Sandra G. Morrison1,2 and Richard P. Morrison1,2,3*

Department of Microbiology, Montana State University, Bozeman, Montana,1 Division of Infectious Diseases, Department of Medicine,2 Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama3

Received 29 March 2005/ Returned for modification 4 May 2005/ Accepted 6 May 2005

The resolution of primary and secondary chlamydial genital infection in immunoglobulin A (IgA)-deficient (IgA–/–) mice was not different from that in IgA+/+ mice. Furthermore, depletion of either CD4+ or CD8+ T cells prior to reinfection of IgA+/+ or –/– mice had limited impact on immunity to reinfection. Thus, although antibody contributes importantly to immunity to chlamydial genital tract reinfection, IgA antibodies are not an absolute requirement of that protective response.

* Corresponding author. Mailing address: Department of Medicine, Division of Infectious Diseases, ZRB 216, 703 19th St. S., Birmingham, AL 35294-0007. Phone: (205) 996-2795. Fax: (205) 975-7764. E-mail: rpm{at}uab.edu.

Editor: J. D. Clements

Infection and Immunity, September 2005, p. 6183-6186, Vol. 73, No. 9
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.9.6183-6186.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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