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Infection and Immunity, September 2005, p. 6194-6197, Vol. 73, No. 9
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.9.6194-6197.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Viability of a Capsule- and Lipopolysaccharide-Deficient Mutant of Neisseria meningitidis

Department of Molecular Microbiology and Institute for Biomembranes, Utrecht University, 3584 CH Utrecht, The Netherlands

Received 25 February 2005/ Returned for modification 30 March 2005/ Accepted 4 May 2005

Neisseria meningitidis is the only lipopolysaccharide (LPS)-producing gram-negative bacterial species shown to be viable also without LPS. It was thought that the presence of capsular polysaccharide is necessary for this unusual feature. However, we show now that no part of the capsule gene cluster is required for maintaining LPS deficiency in N. meningitidis.

Editor: J. N. Weiser

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