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Infection and Immunity, January 2006, p. 721-728, Vol. 74, No. 1
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.1.721-728.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Identification of the Vibrio vulnificus wbpP Gene and Evaluation of Its Role in Virulence

Na Young Park,1 Jeong Hyun Lee,1 Myung Won Kim,1 Hee Gon Jeong,1 Byung Cheol Lee,2 Tae Sung Kim,2 and Sang Ho Choi1*

Department of Food Science and Technology, School of Agricultural Biotechnology, and Center for Agricultural Biomaterials, Seoul National University, Seoul 151-742,1 School of Life Sciences and Biotechnology, Korea University, Seoul 136-701, South Korea2

Received 22 April 2005/ Returned for modification 29 July 2005/ Accepted 27 September 2005

A wbpP gene encoding a putative UDP-N-acetyl-D-glucosamine C4 epimerase was identified and cloned from Vibrio vulnificus. The functions of the wbpP gene, assessed by the construction of an isogenic mutant and by evaluating its phenotype changes, demonstrated that WbpP is essential in both the pathogenesis and the capsular polysaccharide biosynthesis of V. vulnificus.

* Corresponding author. Mailing address: Department of Food Science and Technology, School of Agricultural Biotechnology, Center for Agricultural Biomaterials, Seoul National University, Seoul 151-742, South Korea. Phone: 82-2-880-4857. Fax: 82-2-873-5095. E-mail: choish{at}snu.ac.kr.

Editor: V. J. DiRita

Infection and Immunity, January 2006, p. 721-728, Vol. 74, No. 1
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.1.721-728.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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