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Infection and Immunity, January 2006, p. 729-733, Vol. 74, No. 1
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.1.729-733.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Inhibition of Macrophage Apoptosis by Neisseria meningitidis Requires Nitric Oxide Detoxification Mechanisms

Anne J. Tunbridge,1,{dagger} Tania M. Stevanin,1,{dagger} Margaret Lee,1 Helen M. Marriott,1 James W. B. Moir,2 Robert C. Read,1 and David H. Dockrell1*

Division of Genomic Medicine, University of Sheffield, Sheffield, United Kingdom,1 Department of Biology, University of York, York, United Kingdom2

Received 28 June 2005/ Returned for modification 23 August 2005/ Accepted 26 September 2005

Host-driven macrophage apoptosis contributes to innate immunity during bacterial infection. Neisseria meningitidis inhibits apoptosis in a variety of cells, but its impact on macrophage apoptosis is unknown. We demonstrate that N. meningitidis prevents macrophage apoptosis via genes encoding nitric oxide detoxification and a porin, PorB.

* Corresponding author. Mailing address: Division of Genomic Medicine, F-Floor, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, United Kingdom. Phone: 44 114 271 2027. Fax: 44 114 271 3892. E-mail: d.h.dockrell{at}sheffield.ac.uk.

Editor: F. C. Fang

{dagger} A.J.T. and T.M.S. contributed equally to this work.

Infection and Immunity, January 2006, p. 729-733, Vol. 74, No. 1
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.1.729-733.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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