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Infection and Immunity, January 2006, p. 729-733, Vol. 74, No. 1
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.1.729-733.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Inhibition of Macrophage Apoptosis by Neisseria meningitidis Requires Nitric Oxide Detoxification Mechanisms

Anne J. Tunbridge,^1, Tania M. Stevanin,^1, Margaret Lee,¹ Helen M. Marriott,¹ James W. B. Moir,² Robert C. Read,¹ and David H. Dockrell^1*

Division of Genomic Medicine, University of Sheffield, Sheffield, United Kingdom,¹ Department of Biology, University of York, York, United Kingdom²

Received 28 June 2005/ Returned for modification 23 August 2005/ Accepted 26 September 2005

Host-driven macrophage apoptosis contributes to innate immunity during bacterial infection. Neisseria meningitidis inhibits apoptosis in a variety of cells, but its impact on macrophage apoptosis is unknown. We demonstrate that N. meningitidis prevents macrophage apoptosis via genes encoding nitric oxide detoxification and a porin, PorB.

Editor: F. C. Fang

A.J.T. and T.M.S. contributed equally to this work.

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