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Infection and Immunity, January 2006, p. 734-739, Vol. 74, No. 1
0019-9567/06/$08.00+0 doi:10.1128/IAI.74.1.734-739.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.
Association between Epithelial Cell Death and Invasion by Microspheres Conjugated to Porphyromonas gingivalis Vesicles with Different Types of Fimbriae
Hiroaki Inaba,1
Shinji Kawai,1
Takahiro Kato,1
Ichiro Nakagawa,2 and
Atsuo Amano1*
Departments of Oral Frontier Biology,1
Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita-Osaka 565-0871, Japan2
Received 14 July 2005/
Returned for modification 29 August 2005/
Accepted 9 October 2005
Microspheres
(MS) conjugated to Porphyromonas gingivalis vesicles with type
II fimbriae were the most efficient human epithelial cell invaders
among the six types. Cell death was induced by MS, though becoming less
frequent over time, with invasion efficiency partially related to cell
death and gingipains likely the major
cause.
* Corresponding
author. Mailing address: Department of Oral Frontier Biology, Osaka
University Graduate School of Dentistry, 1-8 Yamadaoka, Suita-Osaka
565-0871, Japan. Phone: 81-6-6879-2976. Fax: 81-6-6876-8455. E-mail:
amanoa{at}dent.osaka-u.ac.jp.
Editor: J. D. Clements
Infection and Immunity, January 2006, p. 734-739, Vol. 74, No. 1
0019-9567/06/$08.00+0 doi:10.1128/IAI.74.1.734-739.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.
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