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Infection and Immunity, January 2006, p. 734-739, Vol. 74, No. 1
0019-9567/06/$08.00+0     doi:10.1128/IAI.74.1.734-739.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Association between Epithelial Cell Death and Invasion by Microspheres Conjugated to Porphyromonas gingivalis Vesicles with Different Types of Fimbriae

Departments of Oral Frontier Biology,¹ Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita-Osaka 565-0871, Japan²

Received 14 July 2005/ Returned for modification 29 August 2005/ Accepted 9 October 2005

Microspheres (MS) conjugated to Porphyromonas gingivalis vesicles with type II fimbriae were the most efficient human epithelial cell invaders among the six types. Cell death was induced by MS, though becoming less frequent over time, with invasion efficiency partially related to cell death and gingipains likely the major cause.

Editor: J. D. Clements

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